After mocking the Quartermaster for his youthful appearance, the boffin hazards that he "can do more damage on his laptop in his pyjamas than Bond can do in a year in the field." Commenting on 007's usefulness to MI6 he admits that "every now and again a trigger needs to be pulled." Bond quips, "Or not pulled. It's hard to know which in your pyjamas." The two formally acknowledge one another and exchange a friendly handshake, a mutual respect between the pair forming.

He then hands Bond the ticket to Shanghai and his new field equipment: a biometrically-encoded Walther PPK (coded to Bond's palm-prints) and a radio transmitter for tracing Bond's whereabouts in the field. 007 is rather underwhelmed by his new equipment, causing Q to retort "Were you expecting an exploding pen? We don't really go in for those anymore." Standing up to leave, Q wishes Bond luck and to return the equipment in one piece. Q is afraid of flying as mentioned by Eve Moneypenny when she arrives in Bond's hotel room in Macau.

After Bond arrested Silva, M orders Q to try and check his computer. Trying to break the code, proved to be difficult as Q quips that it's "like trying to solve a Rubik's cube that is fighting back." Bond soon tells him to stop and discovers a series of words which spell out 'Grandborough', that is an old tube station. Seeing the doors open, Bond realises Silva got into the system and runs to the detainment cell. Seeing a hacking warning, Q angrily yells to his techs to ask him how he got into the system. Seeing a message on the laptop, Q quickly tries to unplug it, but was too late and realises that Silva hacked them.

Getting contact from 007 while he was in pursuit of Silva, Q provided directions and found that getting caught was part of Silva's plan so he can escape. After hacking into the security cameras in the London Underground he quickly identifies Silva, who is disguised as a policeman and has Bond get on the train as it departs. Upon being told that Silva is after M, Q messages Tanner during the inquiry to get her out, but she refuses to rudely leave. After Bond rescued M from Silva's attack on the inquiry he quickly drives her away from the courtroom and heads to his apartments storage garage where he switches the car with his Aston Martin DB5. Bond instructs Q to leave an electronic trail for Silva to follow, a decision Mallory supports. While Bond drives M to Skyfall, Q begins to lay the trail of breadcrumbs for Silva and Bond and M set traps at Skyfall and await the arrival of Silva.

Following 007's suspension he is reported After Bond asks him to make him disappear and Q retorts that he answers directly to M and has a mortgage and and two cats to feed, which Bonds threatens the lives of the cats if he doesn't make him disappear.

Q keeps Bond's location a secret for 24 hours. The following day arriving at work, he finds that 007 has stolen the new Aston Martin DB10 car assigned to 009 and left a bottle of Bollinger Champagne for Q. Q meets 007 in Austria where he outruns Spectre agents after a ring he eventually decodes, revealing the organization's existence.

Q later returns to London to assist Moneypenny and M in foiling Max Denbigh's launch of the Nine Eyes intelligence network. Finally After an extensive rebuild he provides Bond with his remodeled Aston Martin DB5.